Curcuma longa Mediated Synthesis of Copper Oxide, Nickel Oxide and Cu-Ni Bimetallic Hybrid Nanoparticles: Characterization and Evaluation for Antimicrobial, Anti-Parasitic and Cytotoxic Potentials

Nanoparticles have long been known and their biomedical potent activities proven that these can provide an alternative to other drugs. In the current study, copper oxide, nickel oxide copper/nickel hybrid NPs were biosynthesized by using Curcuma longa root extracts as a reducing capping agent, followed characterization via UV-spectroscopy, Fourier transformed infrared spectroscopy (FTIR), energy dispersive X-ray (EDX), powder diffraction (XRD), scanning electron microscopy (SEM), transmission (TEM), thermo galvanometric analysis (TGA), band gap. FTIR shows availability of various functional groups biomolecules such carbohydrate, protein, polysaccharides, etc. The EDX peak confirmed elemental present in large quantity analyzed sample. Scanning micrographs showed synthesized CuO-NPs NiO-NPs polyhedral uniform homogeneous morphology, while well dispersed, spherical shape, size. TEM had 27.72 nm, NiO 23.13 nm and, for hybrid, size was 17.38 which respectively. CuO possessed spherical- multi-headed shapes, complete small size, polydispersed NPs. XRD spectra revealed average particle CuO, NiO, 29.7 28 27 Maximum anti-diabetic inhibition (52.35 ± 0.76: CuO-NPs, 68.1 0.93: 74.23 0.42: Cu + Ni hybrids) ?-amylase (39.25 0.18 52.35 1.32: 62.32 0.48: ?-glucosidase calculated, respectively, at 400 µg/mL. maximum antioxidants capacity observed 65.1 0.83 ?gAAE/mg Cu-Ni hybrids, 58.39 0.62 NiO-NPs, 52.2 0.31 ?g/mL. highest antibacterial activity against P. aeuroginosa (28 1.22) vulgaris (25 1.73) Furthermore, antibiotics coated with NPs, noted. Significant anti-leishmanial 60.5 0.53 68.4 0.59 hybrids; 53.2 0.48 61.2 0.44 NiO-NPs; 49.1 0.39 56.2 0.45 ?g/mL recorded promastigote amastigotes, also significant anti-cancerous potential HepG2 cell lines. It concluded from study are agents be used antimicrobial agents.